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Descriere Background: Uveitis is a potentially blinding complication of juvenile idiopathic arthritis JIA. Treatment remains a substantial challenge, even though the use of tumor necrosis factor TNF -α-antagonists has improved visual outcomes substantially.
Among these agents, adalimumab has been recently approved for the treatment of non-infectious uveitis and is thus the first biologic disease-modifying anti-rheumatic drug bDMARD approved for JIA-associated uveitis.
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However, some patients do not respond sufficiently or lose response over time. Recently golimumab, a fully humanized anti-TNF-α monoclonal antibody, demonstrated efficacy in a small case series, leading to uveitis inactivity in 4 of 7 patients Golimumab is approved for the treatment of polyarticular JIA.
Hypothesis: Patients with JIA-associated uveitis failing treatment with adalimumab benefit from the treatment with golimumab.
All patients that have started golimumab from March are included in the study. Primary failure to adalimumab was diagnosed in patients without change in the SUN score and an entry grade of 3 or higher or with worsening activity, defined as either a two-grade increase in inflammation or an increase to grade 4.
With bilateral disease, the eye with the higher grade of uveitis was analysed. Relapse of uveitis was defined as active inflammation after an inactivity for at least 3 months.
- We conducted a multicenter study of patients with JIA-associated uveitis that was refractory to conventional immunosuppressive drugs and anti-tumor necrosis factor anti-TNF agents.
- Dureri de umăr fără inflamații
- Он просиял.
- Tot despre bolile articulare
- PARTICULARITĂŢI DIAGNOSTICE ÎN UVEITELE REUMATISMALE LA COPII ŞI ADOLESCENŢI
- Top psoriazis pediatric adalimumab
Loss of response was defined as failure to improve under continued treatment with adalimumab despite intermitting intensifying concomitant therapy, such as local or juvenile idiopathic arthritis with uveitis steroids. Golimumab treatment was administered in the standard dose of 50 mg sc every 4 weeks in patients with a weight of at least 40 kg.
The outcome measures of uveitis include the reduction in grade of intraocular inflammation, the best-corrected visual acuity, eye soreness, redness of eyes, light sensitivity and the steroid sparing potential.
Response to treatment is classified as complete, partial infiltratii gonartroza no response.
Complete response constitute achieving inactive uveitis, defined as Patients receiving Golimumab were evaluated clinically and immunologically at regular intervals. At each visit the laboratory analysis included complete blood cell counts, levels of creatinine, hepatobiliary-injury biomarkers, and C-reactive protein.
Juvenile Idiopathic Arthritis
Side effects were assessed by patient's reported history. Statistical analysis Continuous variables will be analyzed by Student's t-test or Mann-Whitney U test.
Correlations will be analyzed by Spearman's rank correlation test. Binary variables were analyzed using Fisher's exact test.
Inhibitori ai pde4 psoriazis Adalimumab has been studied in several thousand adult patients with moderate to severe psoriasis. The efficacy of the medication was judged using PASI Psoriasis Area and Severity Index scores before treatment and after using adalimumab 40 mg every 2 weeks. Psoriazis n plci la copii i adolesceni Humira este indicat pentru tratamentul psoriazisului n plci cronic sever la copii i adolesceni cu vrsta ncepnd de la 4 ani care. Psoriazis - o noua optiune terapeutica - Psoriazisul este o boala a Ustekinumab fata de Etanercept in tratamentul psoriazisului in placi, forme Psoriazisul - Generalitati; 5 manageri de top din Romania iesiti din tipare Pediatrie · Pneumoftiziologie · Nutritie · Reumatologie · Stomatologie · Urologie.
Statistical significance was defined as p Datele.